SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                 SCHEDULE 13D/A
   
                 Under the Securities Exchange Act of 1934
                            (Amendment No. 1)*
                                          ---------
    

                      La Jolla Pharmaceutical Company
           --------------------------------------------------------
                                (Name of Issuer)

                 Common Stock, par value $.01 per share
           --------------------------------------------------------
                          (Title of Class of Securities)

                            503   459   10   9
           --------------------------------------------------------
                                 (CUSIP Number)

           Jose M. de Lasa, Abbott Laboratories, AP6D D-364,
           100 Abbott Park Road; Abbott Park, Illinois 60064-3500;
           phone (847) 937-8905
           --------------------------------------------------------
           (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)
   
                                September 9, 1997
           --------------------------------------------------------
    
            (Date of Event which Requires Filing of this Statement)
   
   If the  filing  person has  previously filed a  statement on Schedule 13G to
report the  acquisition  which  is the  subject  of this  Schedule 13D,  and is
filing this  schedule  because of Rule 13d-1(b)(3) or (4),  check the following
box /x/.
    

   Check the following box if a fee is being paid with this statement  / /.  (A
fee is not required only if the reporting person:  (1) has a previous statement
on file  reporting  beneficial ownership of more than five percent of the class
of securities  described in Item 1;  and  (2) has filed no amendment subsequent
thereto  reporting  beneficial ownership of five percent or less of such class.
(See Rule 13d-7.)

   NOTE:  Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are to
be sent.

   *The remainder of  this cover  page  shall  be  filled  out  for a reporting
person's  initial  filing on this  form with  respect to the  subject  class of
securities,  and for any  subsequent  amendment  containing  information  which
would alter disclosures provided in a prior cover page.

   The information  required on the  remainder of this  cover page shall not be
deemed to be "filed"  for the purpose of  Section 18 of the Securities Exchange
Act of 1934  ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however, see
the Notes).


                        (Continued on following page(s))

                              Page 1 of     Pages
                                        --- 



CUSIP No. 503 459 10 9         13D                 Page  2  of     Pages
          ------------                                  ---    --- 


- -------------------------------------------------------------------------------
 (1) Names of Reporting Persons.  S.S. or I.R.S. Identification Nos. of Above
     Persons

                 Abbott Laboratories
                 IRS Identification Number:  36-0698440

- -------------------------------------------------------------------------------
 (2) Check the Appropriate Box if a Member     (a)  / /
     of a Group*                               (b)  /x/
- -------------------------------------------------------------------------------
 (3) SEC Use Only

- -------------------------------------------------------------------------------
 (4) Source of Funds*

         WC
- -------------------------------------------------------------------------------
 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to
     Items 2(d) or 2(e)                             / /
- -------------------------------------------------------------------------------
 (6) Citizenship or Place of Organization

          Illinois
- -------------------------------------------------------------------------------
   
Number of Shares              (7) Sole Voting
 Beneficially Owned                 Power        1,831,202
 by Each Reporting           --------------------------------------------------
 Person With                  (8) Shared Voting
                                    Power
                             --------------------------------------------------
                              (9) Sole Dispositive
                                    Power        1,831,202
                             --------------------------------------------------
                             (10) Shared Dispositive
                                    Power
- -------------------------------------------------------------------------------
(11) Aggregate Amount Beneficially Owned by Each Reporting Person
         1,831,202
- -------------------------------------------------------------------------------
(12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares*
                                                     / /
- -------------------------------------------------------------------------------
(13) Percent of Class Represented by Amount in Row (11)
         10.57%
    
- -------------------------------------------------------------------------------
(14) Type of Reporting Person*
         CO

- -------------------------------------------------------------------------------
                    *SEE INSTRUCTION BEFORE FILLING OUT!



The following information amends and supplements the Schedule 13D filed on 
January 2, 1997 (the "Schedule 13D").

ITEM 1.  SECURITY AND ISSUER
   

         This statement relates to the common stock, par value $.01 per 
share (the "Common Stock"), of La Jolla Pharmaceutical Company, a Delaware 
corporation (the "Issuer"), whose principal executive offices are located at 
6455 Nancy Ridge Drive, San Diego, California 92121.

    

ITEM 2.  IDENTITY AND BACKGROUND

         (a) - (c), and (f)  The person filing this statement is Abbott
Laboratories ("Abbott"), an Illinois corporation.  Abbott's principal business
is the discovery, development, manufacture, and sale of a broad and diversified
line of health care products and services.  Abbott's principal office is located
at 100 Abbott Park Road, Abbott Park, Illinois 60064-3500.

         The names, citizenship, business addresses, present principal
occupation or employment and the name, and the principal business and address of
any corporation or other organization in which such employment is conducted of
the directors and executive officers of Abbott are as set forth in Exhibit 1
hereto and incorporated herein by this reference.

         (d) and (e)    Neither Abbott, nor to the best of its knowledge, any 
person listed on Exhibit 1 has during the last five years (i) been convicted 
in a criminal proceeding (excluding traffic violations or similar 
misdemeanors) or (ii) been a party to a civil proceeding of a judicial or 
administrative body of competent jurisdiction and as a result of such 
proceeding was or is subject to a judgment, decree or final order enjoining 
future violations of, or prohibiting or mandating activities subject to, 
federal or state securities laws or finding any violation with respect to 
such laws.

ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION
   

         The consideration used by Abbott for the acquisition reported in 
this First Amendment to Schedule 13D came from the working capital of Abbott. 
The purchase price for the 831,152 shares of Common Stock acquired by Abbott 
since the date on which the Schedule 13D was filed, as described in Item 4, 
was four million dollars ($4,000,000). The aggregate purchase price for the 
1,831,202 shares of Common Stock owned by Abbott was eight million dollars 
($8,000,000) all of which came from the working capital of Abbott. 

         K. Frank Austen, M.D., a director of Abbott, has advised Abbott that 
he is the beneficial owner of 2,500 shares of Common Stock, that he holds 
options to purchase an additional 36,300 shares of Common Stock (of which, 
options covering 3,300 shares of Common Stock are currently exercisable) and 
that he used his personal assets to acquire his shares of Common Stock. Dr. 
Austen acquired these securities independently of Abbott's acquisitions.

ITEM 4.  PURPOSE OF THE ACQUISITION

    


   

         On September 9, 1997, as the result of the exercise by the Issuer of 
its Additional Investment Right (described below), Abbott purchased 831,152 
shares (the "Shares") of Common Stock. Abbott acquired the Shares as an 
investment and pursuant to the terms and conditions of the Agreement between 
Abbott Laboratories and La Jolla Pharmaceutical Company dated December 23, 
1996 (the "Agreement") (a copy of which is attached to the Schedule 13D as 
Exhibit 2). Dr. Austen has advised Abbott that he acquired his shares of 
Common Stock as an investment.

         (a) Under Section 2(b) of the Agreement, the Issuer has the right 
(the "Additional Investment Right") to require Abbott to purchase additional 
shares of the Issuer's Common Stock ("Additional Shares").  The Additional 
Investment Right is described in greater detail in Item 6 to the Schedule 13D.

    

         (b) - (j) At present, Abbott does not have (and has been advised by 
Dr. Austen that he does not have) any plans or proposals which would relate 
to or result in transactions of the kind described in paragraphs (b) through 
(j) of Item 4 of schedule 13D of the Securities and Exchange Commission.  
They do, however, reserve the right to adopt such plans or proposals subject 
to compliance with applicable regulatory requirements and, with respect to 
Abbott, its obligations under the Agreement.

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER

   

         (a)  Abbott is the beneficial owner of 1,831,202 shares of the 
Common Stock representing approximately ten and 57/100 percent (10.57%) of 
the outstanding shares of the Common Stock.  

    

         Dr. Austen is the beneficial owner of the shares of Common Stock and 
options described in Item 3.  His shares represent less than one percent of 
the outstanding shares of the Common Stock.  

         The calculation of the foregoing percentages is based on the number 
of shares of Common Stock shown as being outstanding on the Form 10-Q 
Quarterly Report filed by the Issuer with the Securities and Exchange 
Commission for the quarter ended June 30, 1997.

         (b) Abbott has sole power to vote or to direct the vote and the sole 
power to dispose or to direct the disposition of its 1,831,202 shares of 
Common Stock.  Section 5(b) of the Agreement does, however, limit the ability 
of Abbott to sell or transfer any Shares except as allowed by the Agreement.

   
            K. Frank Austen, M.D., a director of Abbott Laboratories, has 
advised Abbott that he is the beneficial owner of 2,500 shares of Common 
Stock and holds options to purchase an additional 36,300 shares of Common 
Stock (of which, options covering 3,300 shares of Common Stock are currently 
exercisable) and that he has sole power to vote or to direct the vote and the 
sole power to dispose or to direct the disposition of his shares of Common 
Stock.
    

         (c)  Except as described herein, there have been no transactions by
Abbott or the persons whose names are listed on Exhibit 1 in securities of the
Issuer during the past sixty days.



         (d)  No one other than Abbott is known to have the right to receive 
or the power to direct the receipt of dividends from, or the proceeds from a 
sale of the shares of Common Stock owned by Abbott.

         (e)  Not applicable.


ITEM 6.  CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH
         RESPECT TO SECURITIES OF THE ISSUER

   

    
   
    There are no contracts, arrangements understandings or relationships 
among the persons named in Item 2 or between either of those persons and any 
other person with respect to securities of the Issuer, except as referred to 
or described herein or in the Schedule 13D.
    
ITEM 7.  MATERIAL TO BE FILED AS EXHIBITS

         Exhibit 1 -    Information Concerning Executive Officers and
                        Directors of Abbott Laboratories.
   
    

                       ***************************************

    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

   
                                            Abbott Laboratories

DATED: September 26, 1997                  By: /s/ Thomas C. Freyman
                                            ________________________________
                                           Thomas C. Freyman,
                                           Vice President and Treasurer
    




                                    EXHIBIT INDEX

Exhibit                                                         Sequential Page
Number     Description                                               Number
- -------    ------------------------------------------------     ---------------
   1       Information Concerning Executive Officers and
           Directors of Abbott Laboratories.
   
    


                                     Exhibit 1

                    Information Concerning Executive Officers and
                           Directors of Abbott Laboratories
                           _______________________________

         The current corporate officers and directors of Abbott Laboratories
    are listed below.  The address of Abbott Laboratories is:  Abbott
    Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-3500.
    Abbott Laboratories does not consider all of its corporate officers to be
    executive officers as defined by the Securities Exchange Act of 1934 or
    Releases thereunder.  Unless otherwise indicated, all positions set forth
    below opposite an individual's name refer to positions within Abbott
    Laboratories, and the business address listed for each individual not
    principally employed by Abbott Laboratories is also the address of the
    corporation or other organization which principally employs that
    individual.


                         POSITION/PRESENT PRINCIPAL OCCUPATION
                         OR EMPLOYMENT
NAME                     AND BUSINESS ADDRESS                     CITIZENSHIP

Corporate Officers
- ------------------

Duane L. Burnham(1)      Chairman of the Board and Chief Executive   U. S. A
                         Officer

Thomas R. Hodgson(1)     President and Chief Operating Officer       U. S. A

Joy A. Amundson(1)       Senior Vice President, Chemical &           U. S. A
                         Agricultural Products

Paul N. Clark(1)         Senior Vice President,                      U. S. A
                         Pharmaceutical Operations

Gary P. Coughlan(1)      Senior Vice President, Finance & Chief      U. S. A
                         Financial Officer

Jose M. de Lasa(1)       Senior Vice President, Secretary and        U. S. A
                         General Counsel

John G. Kringel(1)       Senior Vice President, Hospital Products    U. S. A

Thomas M. McNally(1)     Senior Vice President,                      U. S. A
                         Ross Products

Robert L. Parkinson,     Senior Vice President, International        U. S. A
Jr.(1)                   Operations

Ellen M. Walvoord(1)     Senior Vice President, Human Resources      U. S. A



                                     Exhibit 1

                    Information Concerning Executive Officers and
                           Directors of Abbott Laboratories
                           _______________________________


                         POSITION/PRESENT PRINCIPAL OCCUPATION
                         OR EMPLOYMENT
NAME                     AND BUSINESS ADDRESS                     CITIZENSHIP

Corporate Officers
- ------------------
 Continued

Miles D. White(1)         Senior Vice President, Diagnostic           U. S. A.
                          Operations

Catherine V. Babington(1) Vice President, Investor Relations          U. S. A.
                          and Public Affairs

Patrick J. Balthrop       Vice President, Diagnostic Operations,      U. S. A.
                          U.S. and Canada

Mark E. Barmak            Vice President, Litigation and Government   U. S. A.
                          Affairs

Christopher B. Begley     Vice President, MediSense                   U. S. A.

Thomas D. Brown           Vice President, Diagnostic Commercial       U. S. A.
                          Operations

Gary R. Byers(1)          Vice President, Internal Audit              U. S. A.

William G. Dempsey        Vice President, Hospital Products           U. S. A.
                          Business Sector

Kenneth W. Farmer(1)      Vice President, Management Information      U. S. A.
                          Services & Administration

Thomas C. Freyman(1)      Vice President and Treasurer                U. S. A.

David B. Goffredo         Vice President, Pharmaceutical Products     U. S. A.
                          Marketing & Sales

Rick A. Gonzalez          Vice President, HealthSystems               U. S. A.

Guillermo A. Herrera      Vice President, Latin America Operations    Colombia

Arthur J. Higgins         Vice President, Pacific, Asia, and          United
                          Africa Operations                           Kingdom

Jay B. Johnston           Vice President, Diagnostic Assays and       U. S. A.
                          Operations



                                    Exhibit 1

                    Information Concerning Executive Officers and
                           Directors of Abbott Laboratories
                           _______________________________


                         POSITION/PRESENT PRINCIPAL OCCUPATION
                         OR EMPLOYMENT
NAME                     AND BUSINESS ADDRESS                     CITIZENSHIP

Corporate Officers
- ------------------
 Continued

James J. Koziarz, Ph.D.  Vice President, Diagnostic Products         U. S. A.
                         Research & Development

John F. Lussen(1)        Vice President, Taxes                       U. S. A.

Edward L. Michael        Vice President, Diagnostic Operations,      U. S. A.
                         Europe, Africa, and Middle East

Theodore A. Olson(1)     Vice President and Controller               U. S. A.

Andre G. Pernet, Ph.D.   Vice President, Pharmaceutical              U. S. A.
                         Products Research & Development

Carl A. Spalding         Vice President, Ross Pediatric Products     U. S. A.

William H. Stadtlander   Vice President, Ross Medical Nutritional    U. S. A.
                         Products

Marcia A. Thomas(1)      Vice President, Corporate Quality           U. S. A.
                         Assurance & Regulatory Affairs

H. Thomas Watkins        Vice President, Diagnostic Operations,      U. S. A.
                         Asia and Pacific

Steven J. Weger(1)       Vice President, Corporate Planning and      U. S. A.
                         Development

Josef Wendler            Vice President, European Operations         Germany

Lance B. Wyatt(1)        Vice President, Corporate Engineering       U. S. A.

Directors
- ---------

K. Frank Austen, M.D.    Professor of Medicine, Harvard Medical      U. S. A.
                         School
   
                                 Brigham & Women's
                                  Hospital
                                 Smith Building
                                 Room 638
                                 75 Francis Street
                                 Boston, Massachusetts 02115
    
Duane L. Burnham         Officer of Abbott                           U. S. A.



                                    Exhibit 1

                    Information Concerning Executive Officers and
                           Directors of Abbott Laboratories
                           _______________________________


                         POSITION/PRESENT PRINCIPAL OCCUPATION
                         OR EMPLOYMENT
NAME                     AND BUSINESS ADDRESS                     CITIZENSHIP

Directors - Continued
- ---------------------

H. Laurance Fuller       Chairman, President, and Chief Executive    U. S. A.
                         Officer
                                 Amoco Corporation
                                 200 East Randolph Drive
                                 Mail Code 3000
                                 Chicago, Illinois 60601
                                 (integrated petroleum and chemicals
                                 company)

Thomas R. Hodgson        Officer of Abbott                           U. S. A.

   

    

David A. Jones           Chairman and Chief Executive Officer        U. S. A.
                                 Humana Inc.
                                 500 W. Main St.
                                 Humana Building
                                 Louisville, Kentucky 40201
                                 (Health Plan Business)

The Rt. Hon. the Lord    British Member of Parliament                United
Owen CH                          20 Queen Anne's Gate                Kingdom
                                 Westminster, London
                                 SW1H 9AA, England

Boone Powell, Jr.        President and Chief Executive Officer       U. S. A.
                                 Baylor Health Care System and
                                 Baylor University Medical Center,
                                 Vice President, Baylor University
                                 3500 Gaston Avenue
                                 Dallas, Texas 75246



                                    Exhibit 1

                    Information Concerning Executive Officers and
                           Directors of Abbott Laboratories
                           _______________________________


                         POSITION/PRESENT PRINCIPAL OCCUPATION
                         OR EMPLOYMENT
NAME                     AND BUSINESS ADDRESS                     CITIZENSHIP

Directors - Continued
- ---------------------

Addison Barry Rand       Executive Vice President                    U. S. A.
                                 Xerox Corporation
                                 800 Long Ridge Road
                                 Stamford, Connecticut
                                 06904-1600
                                 (document processing, insurance and
                                 financial services company)
   

Dr. W. Ann Reynolds      President                                   U. S. A.
                                 The University of Alabama at Birmingham
                                 Suite 1070 Administration Building
                                 701 South 20th St.
                                 Birmingham, Alabama
                                 35294-0110
    

William D. Smithburg     Chairman, President and Chief Executive     U. S. A.
                         Officer
                                 The Quaker Oats Company
                                 321 N. Clark Street
                                 Chicago, Illinois 60610
                                 (worldwide food manufacturer and
                                 marketer of beverages and grain-
                                 based products)
   

John R. Walter                   401 North Ahwahnee Road             U. S. A.
                                 Lake Forest, Illinois 60045
    

William L. Weiss         Chairman Emeritus, Ameritech Corporation    U. S. A.
                                 One First National Plaza
                                 Suite 2530C
                                 Chicago, Illinois 60603-2006
                                 (telecommunications company)



(1) Pursuant to Item 401(b) of Regulation S-K Abbott has identified these
    persons as "executive officers" within the meaning of Item 401(b).